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D-mannose is a 6-carbon sugar and an isomer of dextrose. D-mannose is used by the body for the glycosylation of proteins and fibroblast activity. It is present in small amounts in the blood. Research suggests supplemental D-mannose might interfere with the adhesion of Escherichia coli bacteria to the urinary tract, theoretically protecting from some urinary tract infections (UTIs). D-mannose is used orally to treat urinary tract infections (UTIs), and for treating carbohydrate-deficient glycoprotein syndrome, an inherited metabolic disorder. D-mannose is thought to help with urinary tract help by encouraging the binding and flushing of bacteria. 

Also known as:  Carubinose, D-Manosa, Mannose, Seminose

Diseases and Conditions

D-mannose is primarily used to support urinary tract health. Additionally, D-mannose has been used to support those with carbohydrate-deficient glycoprotein syndrome. There is some research that supports that D-mannose supplementation can help with protein loss, liver function, decreased blood sugar, and blood clotting issues. 


D-mannose is possibly safe when used orally and appropriately.

There is insufficient information on the safety of D-mannose for children, pregnant, and breastfeeding women, so it is best to avoid.

Side effects of d-mannose may include abdominal bloating and loose stools. Excessive use of d-mannose might be toxic for the kidneys. There are also some concerns that d-mannose may have mutagenic or teratogenic properties. Patients with diabetes should not consume D-mannose.

Medication Interactions

There are no known medication interactions for D-mannose.

Supplement and Food Interactions

There are no known supplement, herb, or food interactions for D-mannose.


It is suggested that adults consume 1-3 teaspoons of d-mannose daily, taken with meals.


D-mannose is found naturally in different types of fruits such as cranberries and pineapples. It is also found in blueberries and apples. This macronutrient is absorbed from the gastrointestinal tract and is not stored in the liver or converted into glycogen which is highly unusual for a sugar. Instead, it is primarily excreted through urination and not stored. 

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  1. https://naturalmedicines.therapeuticresearch.com/references.aspx?productid=1114
  2. https://kresserinstitute.com/%EF%BF%BCtreat-prevent-utis-without-drugs/

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