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Manganese is an essential element and trace mineral that can be found in small amounts throughout the body, primarily in the bones, liver, kidneys, and pancreas. The body uses manganese to help support and produce connective tissue, bones, sex hormones, and factors related to blood clotting, as well as to help with fat and carbohydrate metabolism, calcium absorption, and to manage blood sugar levels. Additionally, manganese is used to support healthy brain and nerve function in the body. Deficiency in manganese can lead to infertility, bone deformities, weakness, and even seizures. It is estimated that 37% of Americans are not getting enough manganese through their diet. This may be due to the fact that the average U.S diet has more refined grains than whole grains. Refine grains contain only half the amount of manganese than present in whole grains. Conversely, too much manganese can lead to brain issues such as Parkinson's disease or other neurologic issues.

Also known as:  Aminoate de Manganèse, Ascorbate de Manganèse, Chlorure de Manganèse, Citrate de Manganèse, Complexe Aspartate de Manganèse, Dioxyde de Manganèse, Gluconate de Manganèse, Glycérophosphate de Manganèse, Manganèse, Manganese Amino Acid Chelate, Manganese Aminoate, Manganese Ascorbate, Manganese Aspartate Complex, Manganese Chloride, Manganese Chloridetetrahydrate, Manganese Citrate, Manganese Dioxide, Manganese Gluconate, Manganese Glycerophosphate, Manganese Sulfate, Manganese Sulfate Monohydrate, Manganese Sulfate Tetrahydrate, Manganeso, Manganum, Monohydrate de Sulfate de Manganèse, Sulfate de Manganèse

Diseases and Conditions

Manganese promotes bone health and has been used in the treatment of osteoporosis. Clinical studies have shown that manganese may help alleviate pain in arthritis patients. Other studies have linked manganese to relieving premenstrual syndrome (PMS), diabetes and epilepsy. More clinical studies are needed.


While manganese is a natural and essential element of the human diet, manganese supplement should be adminstered under the guidance of a medical professional to gauge safety.

Medication Interactions

Manganese supplements may interact with:

  • Haloperidol and other antipsychotics
  • Reserpine
  • Antacids
  • Laxatives
  • Tetracycline antibiotics
  • Quinolone antibiotics

Supplement and Food Interactions

Manganese supplements may interact with calcium, IP-6, iron and zinc supplements. Avoid mixing magnanese with these supplements. 


Orally; supplements and dietary intake of manganese together should not exceed 10 milligrams per day.


Some whole grains, nuts, and seeds contain manganese. 

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