Bacillus Coagulans

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Bacillus coagulans is a type of bacteria which is used similarly to lactobacillus and other probiotics as beneficial bacteria.  Bacillus coagulans produces lactic acid and, as a result, is often misclassified as lactic acid bacteria such as lactobacillus. Unlike lactic acid bacteria such as lactobacillus or bifidobacteria, Bacillus coagulans forms reproductive structures called spores which is an important factor in telling Bacillus coagulans apart from lactic acid bacteria. Some research in animals (but not yet in humans) shows that Bacillus coagulans might increase immune system function and decrease harmful bacteria.

Also known as:  B. Coagulans, Bacillus Bacteria, Bacillus Probiotics, Bactéries Bacilles, Bactéries à Gram Positif Sporogènes, Bactérie Gram Positive en Forme de Bâtonnet, Gram Positive Spore-Forming Rod, L. Sporogenes, Lactobacillus Sporogenes, Lactobacillus Sporogènes, Probiotic, Probiotique, Spore-Forming Lactobacillus

Diseases and Conditions

  • Diarrhea: viral diarrhea in children, traveler's diarrhea, and diarrhea caused by antibiotics
  • Growth of bacteria in the intestine: early evidence shows that using a specific probiotic product (Lactol, Bioplus Life Sciences Pvt. Ltd., India) containing Bacillus coagulans and fructo-oligosaccharides twice daily for 15 days per month for 6 months might modestly decrease stomach pain and gas in people with of potentially harmful bacteria in the intestine
  • Helicobacter pylori infection, which causes stomach ulcers
  • Inflammatory bowel disease (IBD, Crohn's disease, ulcerative colitis)
  • As an agent added to vaccines to improve their effectiveness
  • Cancer prevention
  • Clostridium difficile colitis
  • Digestion problems
  • Immune system strengthening
  • Irritable bowel syndrome (IBS)
  • Respiratory infections

More evidence is needed to rate Bacillus coagulans for these uses. 


Bacillus coagulans is possibly safe when taken orally for up to 6 months. There is insufficient information on the overall safety of Bacillus coagulans on children, pregnant, and breastfeeding women; best to avoid. There have been no reported adverse reactions to Bacillus coagulans because of a lack of clinical studies in humans.

Medication Interactions

Bacillus Coagulans can be killed or inhibited by antibiotics, decreasing its potency. Bacillus Coagulans might have immunomodulating activity, and might debilitate immunosuppressants. Some of these drugs include:

  • Azathioprine (Imuran)
  • Basiliximab (Simulect)
  • Cyclosporine (Neoral, Sandimmune)
  • Daclizumab (Zenapax)
  • Muromonab-CD3 (OKT3, Orthoclone OKT3)
  • Mycophenolate (CellCept)
  • Tacrolimus (FK506, Prograf)
  • Sirolimus (Rapamune)
  • Prednisone (Deltasone, Orasone)
  • Corticosteroids (glucocorticoids)

Supplement and Food Interactions

There are no known supplement or food interactions for bacillus coagulans. 


The correct dosage of any supplement requires a comprehensive analysis of many factors including your age, sex, health conditions, DNA, and lifestyle.

The appropriate dose of Bacillus coagulans depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Bacillus coagulans. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


Bacillus coagulans is a type of bacteria which is thought to aid in digestion. However, when this probiotic is present in stored or canned foods, it can cause them to spoil.

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