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L-Arginine is an essential amino acid supplement, used for protein synthesis. It is found naturally in foods such as red meat, poultry, fish, and dairy. Amino acids produce nitric oxide, which improves blood flow. This supplement is commonly used by athletes to ultimately improve performance. However, oral supplements may not reliably improve blood flow in humans.

Also known as:  (2S)-2-Amino-5-[[amino (imino) methyl]amino]pentanoic Acid, (S)-2-Amino-5- Guanidinopentanoic Acid, Acide 2-Amino-5-Guanidinopentanoïque, Arg, Arginine, Arginine Ethyl Ester, Arginine Ethyl Ester Dihydrochloride, Arginine Ethyl Ester HCl, Arginine HCl, Arginine Hydrochloride, Di-Arginine Malate, Di-Arginine Orotate, Di-L-Arginine-L-Malate, Dl-Arginine, L-Arginina, L-Arginine Ethyl Ester Dichloride, L-Arginine HCl, L-Arginine Hexanoate, L-Arginine Hydrochloride, L-Arginine Ketoisocaproic Acid, L-Arginine L-Pyroglutamate, L-Arginine Pyroglutamate, L-Arginine Taurinate, Malate de Di-Arginine, Orotate de Di-Arginine, R-Gene 10

Diseases and Conditions

This supplement is thought to improve nitric oxide. Nitric oxide plays major roles in cardiovascular health (including blood flow and pressure), immune response, inflammation, anti-thrombotic activity, and memory formation. However, there is not enough scientific research to back these health claims.


L-Arginine is possibly safe when orally and appropriately used.

Medication Interactions

No medication interactions reported. 

Supplement and Food Interactions

Do not mix L-Arginine with agmatine, as it may prevent some neurological effects of agmatine.


The standard pre-workout dose for L-arginine is 3-6g. To maintain elevated arginine levels throughout the day, it may be taken up to three times a day. Does may not exceed 15-18g.


L-Arginine is found naturally in foods such as red meat, poultry, fish, and dairy. 

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  1. https://naturalmedicines.therapeuticresearch.com/references.aspx?productid=875
  2. https://examine.com/supplements/arginine/

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