Dimethylamylamine is a drug that was intended as a nasal decongestant due to its stimulant and vasoconstrictor activity. Dimethylamylamine is commonly used in supplements promoted for weight loss, improving athletic performance, and body building. Some proponents claim that it is a safer alternative to ephedrine. However, there is no reliable information about the pharmacology or safety of this compound. In addition to a nasal decongestant, dimethylamylamine is used orally to improve:
- Cognitive function
- Attention deficit hyperactive disorder (ADHD)
- Weight loss
- Athletic performance
- Body building
Also known as: 1, 3 Dimethylamylamine, 1, 3-Dimethyl-5-Amine, 1, 3-Dimethylamylamine, 1, 3-Dimethylamylamine HCL, 1, 3 Dimethylpentylamine, 1, 3-dimethylpentylamine, 2-amino-4-methylhexane, 2-Hexanamine, 4-Methyl-(9Cl), C7H17N, CAS 105-41-9, 4-methyl-2-hexanamine, 4-methyl-2-hexyl-amine, Dimetilamilamina, Dimethylpentylamine, Diméthylpentylamine, DMAA, Forthan, Forthane, Floradrene, Fouramin, Geranamine, Geranium, Géranium, Metexaminum, Methexaminum, Methylhexanamine, Méthylhexanamine, Methylhexaneamine, MéthylhexanéaminePelargonium, Pentylamine
Diseases and Conditions
Evidence is not sufficient to support claims of weight loss.
Dimethylamylamine is likely unsafe when used orally since it may increase the risk of serious cardiovascular disorders. Dimethylamylamine has been associated with cases of hemorrhagic stroke, lactic acidosis, heat stroke, and death. The New Zealand government prohibits the sale of supplements containing dimethylamylamine to those below 18 years of age because of safety concerns. The US Department of Defense (DoD) temporarily banned the sale of supplements with dimethylamylamine in military stores due to safety concerns. There is insufficient information on the safety of dimethylamylamine for children, pregnant, and breastfeeding women; best to avoid. Adverse reactions caused by dimethylamylamine may include:
- Lack of focus
- Significant increase in heart rate
It has also been linked to serious cases of side effects on the cardiovascular, metabolic, and nervous system and may also cause psychiatric problems. Dimethylamylamine may have vasoconstrictive and stimulant properties which can interfere with surgical procedures; discontinue use at least 2 weeks before the procedure.
Moderate interactions exist with stimulants and cytochrome p450 D26 substrates. The former interaction is only theoretical. while the later has been verified through in vitro and in vivo studies.
Supplement and Food Interactions
It is generally advised to avoid with substances possessing stimulant properties in order to avoid the risk of cardiovascular damage.
No typical dosage of dimethylamylamine has been found.
Although it was falsely believed to exist in geraniums, dimethylamylamine is synthetically created.