What is Diindolymethane and Its Side Effects?

What is Diindolylmethane?

Diindolylmethane is a major active metabolite of indole-3-carbinol, which is a constituent of Cruciferous vegetables such as cabbage, Brussels sprouts, cauliflower, and broccoli. Indole-3-carbinol is thought to be one of the agents responsible for the cancer-protective properties of these vegetables .Researchers are interested in diindolylmethane due to potential activity against breast cancer cells. Diindolylmethane is used orally in the prevention of breast, uterine, and colorectal cancer as well as to prevent benign prostatic hypertrophy (BPH) and treat premenstrual syndrome (PMS).

Also known as:  Diindolymetano, Diidolylméthane, DIM

Diseases and Conditions

There is insufficient reliable information available about the effectiveness of diindolylmethane.


Diindolylmethane is likely safe for use orally in amounts found in food; up to 2-24mg. Diindolylmethane may be safe for use orally for medicinal purposes for up to 12 weeks. It is likely unsafe to consume high doses of diindolylmethane. Children, pregnant, and breastfeeding women may safely use diindolylmethane orally in amounts commonly found in food; there is insufficient information about its safety for them when used in higher amounts. Consuming high doses of diindolylmethane have been associated with:

  • Gastrointestinal distress
  • Hyponatremia
  • Vomiting
  • Mild nausea
  • Headaches

Other possible side effects include:

  • Rashes
  • Hyperglycemia
  • Arthralgias

Individuals with hormone-sensitive cancers and conditions should avoid diindolylmethane.

Medication Interactions

Diindolylmethane has a minor interaction with cytochrome P450 1A2 substrates; be watchful of this combination. Diindolylmethane has moderate interactions with diuretic drugs and estrogens. People taking diindolylmethane along with sodium-depleting diuretics might have an increased risk for hyponatremia. Diindolylmethane might have mild estrogenic or antiestrogenic effects, which means concomitant use of large amounts of diindolylmethane might interfere with hormone replacement therapy.

Diindolylmethane Side Effects

Supplement and Food Interactions

There are no known supplement, herb, or food interactions for diindolylmethane.


For cervical cancer, the recommended dosage is two milligrams per kilogram of DIM daily for twelve weeks. There is insufficient reliable evidence available to determine a dosage for other uses.


Diindolylmethane may be found in a variety of cruciferous or Brassica vegetables, like broccoli, cabbage, and brussels sprouts.


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