What are Black Mulberry Side Effects and Uses?

The usable parts of Black mulberry are the ripened berry and root bark.

The fruit contains small amounts of:

  • Vitamin C
  • Rutin
  • Pectin
    • May have laxative properties

Black mulberry is used orally for chronic rhinitis (nasal inflammation) and as a laxative.

Also known as:  Morera Negra, Mulberry, Mûrier Noir, Purple Mulberry

Diseases and Conditions

Black mulberry was traditionally used for vitality and to support immunity. It may also act as a laxative and can be used to relieve chronic nasal inflammation.

There is not enough scientific research to assign an effectiveness rating to this supplement.


There is insufficient information about the overall safety of Black mulberry; children, pregnant, and breastfeeding women should avoid it.

There have been no reported adverse side effects with the use of Black mulberry. It may have hypoglycemic effects and should be avoided by diabetics. Black mulberry may affect blood glucose levels and should be discontinued at least 2 weeks before surgery.

Medication Interactions

Because of claims that some species of Black mulberry leaves have hypoglycemic effects, monitor blood glucose levels closely.

Taking mulberry leaves in combination with antidiabetes drugs may affect blood glucose control and increase the risk of hypoglycemia. Some antidiabetes drugs include:

  • Insulin
  • Glimepiride (Amaryl)
  • Glyburide (DiaBeta, Glynase PresTab, Micronase)
  • Pioglitazone (Actos)
  • Rosiglitazone (Avandia)
  • Chlorpropamide (Diabinese)
  • Glipizide (Glucotrol)
  • Tolbutamide (Orinase)

Theoretically, Black mulberry might reduce the effects of CYP3A4 and increase levels of drugs metabolized by CYP3A4. Individuals using drugs metabolized by CYP3A4 should use caution when taking black mulberry. Some drugs metabolized by CYP3A4 include:

  • Lovastatin (Mevacor)
  • Ketoconazole (Nizoral)
  • Fexofenadine (Allegra)
  • Itraconazole (Sporanox)
  • Triazolam (Halcion)

Supplement and Food Interactions

Some species of Black mulberry leaves are claimed to reduce blood glucose. This effect may possibly combine with that of other herbs and supplements with hypoglycemic effects, such as guar gum, Panax ginseng, fenugreek, and devil’s claw, increasing the risk of hypoglycemia. Additionally, research suggests that people who are allergic to Black mulberry may also have a cross-allergy to fig.


2-4 milliliters of mulberry syrup or 4.5-15 grams of powder or decoction has been used.


The Black mulberry originated in China and has been cultivated to grow around the world. Its popularity is due to its edible fruit, a juicy blend of tart and sweet. Black mulberries are used for jellies, syrups, and mulberry wine.


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