What is Betaine Anhydrous? Learn More

Betaine is found naturally in many foods and is highly concentrated in beets, spinach, grain, and shellfish. Betaine anhydrous is used orally for homocystinuria caused by cystathionine beta-synthase deficiency, 5,10-methylenetetrahydrofolate reductase deficiency, or cobalamin cofactor metabolism defect. It is also used orally for the following conditions:

  • Hyperhomocysteinemia
  • Alcoholic and nonalcoholic steatohepatitis
  • Methotrexate-induced steatohepatitis
  • Depression
  • Osteoarthritis
  • Congestive heart failure (CHF)
  • Stimulating immune function
  • Improving athletic performance
  • Reducing the risk of colorectal adenoma
  • Promoting fat loss
  • Liver disease

Betaine anhydrous is used topically as an ingredient in toothpastes to reduce the subjective symptoms of dry mouth.

What is Betaine Anhydrous?

Also known as:  2(N, N, N-trimethyl)ammonium-acetate, Betaína Anhidra, Bétaïne Anhydre, Betaine Anhydrous, Bétaïne de Glycine, Bétaïne de Glycocoll, Cystadane, Glycine Betaine, Glycocoll Betaine, Glycylbetaine, Lycine, Oxyneurine, TMG, Trimethyl Glycine, Trimethylbetaine, Trimethylglycine, Trimethylglycine Anhydre

Diseases and Conditions

There is not enough scientific research to assign an effectiveness rating to this supplement for the following conditions:

  • Homocystinuria caused by cystathionine beta-synthase deficiency
  • 5,10-methylenetetrahydrofolate reductase deficiency
  • Cobalamin cofactor metabolism defect
  • Hyperhomocysteinemia
  • Alcoholic and nonalcoholic steatohepatitis
  • Methotrexate-induced steatohepatitis
  • Depression
  • Osteoarthritis
  • Congestive heart failure (CHF)
  • Stimulating immune function
  • Improving athletic performance
  • Reducing the risk of colorectal adenoma
  • Promoting fat loss
  • Liver disease

Safety

Betaine anhydrous is likely safe when used orally and appropriately; it has been approved by the FDA as a prescription product for adults and children.

There is insufficient information on the safety of betaine anhydrous for pregnant and breastfeeding women; best to avoid.

Side effects are highly unlikely among healthy individuals if taken in doses of up to 6 grams per day, up to 12 weeks.

Most other side effects are gastrointestinal in nature, but also include slight increase in risk for developing heart disease, allergic dermatitis, reduced plasma levels of folate, reduced head circumference growth in patients of Rett syndrome, mental changes in those with psychiatric disorders, and changes in body odor.

Medication Interactions

There are no known medication interactions for betaine anhydrous.

Supplement and Food Interactions

There are no known supplement, herb, or food interactions for betaine anhydrous.

Dosage

There is no recommended daily allowance of betaine. Companies that produce betaine powder suggest that two daily doses of 3 grams each be combined with water, juice, milk or formula prior to consumption.

  • For cardiovascular disease, 2-15 grams of betaine has been taken on a daily basis for a period of up to 17 years.
  • For cholesterol levels, 1.5-6 grams of betaine has been used on a daily basis for periods ranging from six weeks to six months.
  • For cardiovascular disease in individuals without hyperhomocysteinemia, 3 grams of betaine has been used twice daily for a period of six weeks.
  • For enhancing exercise performance, 2-5 grams of betaine has been used daily for a period of up to six weeks.
  • For hyperhomocysteinemia, 0.5-6 grams of betaine has been used on a daily basis for up to six months.
  • For treating hyperhomocysteinemia in those with chronic renal failure, 4-6 grams of betaine taken in two doses per day has been taken for a period of up to three months.
  • For weight loss, 3 grams of betaine has been taken twice per daily for 12 weeks, often combined with orange juice.

Foods

Betaine is found in a number of foods. It is present in especially high levels in beets, but it is also found in shrimp and salmon, grains, spinach, dairy, orange juice, and more.

 

Anxiety concerns? Want to lose weight?

Utilize your DNA to take the guesswork out of achieving your goals.

Responses

avatar

Want to get fresh news? Subscribe to Blog!

Get updates of the most trendy news delivered to your email

Want to get fresh news?

Subscribe to Vitagene updates and know more about vitamins